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Buy Mysimba online for weight loss from our pharmacy. What Mysimba is and what it is used for? Mysimba contains 2 active substances: naltrexone hydrochloride and bupropion hydrochloride and is used in obese or overweight adults to manage weight together with a reduced-calorie diet and physical exercise. This medicine works on areas of the brain involved in the control of food intake and energy expenditure. Obesity in adults over 18 years of age is defined as a body mass index greater than or equal to 30 and overweight in adults over 18 years of age is defined as a body mass index greater than or equal to 27 and less than 30. The body mass index is calculated as the measured body weight (kg) divided by the measured height squared (m2 ). Mysimba is approved for use in patients with an initial body mass index of 30 or greater; it can also be given to those with a body mass index between 27 and 30 if they have additional weight-related conditions such as controlled high blood pressure (hypertension), type 2 diabetes or high levels of lipid (fat) in the blood. Mysimba may be discontinued by your doctor after 16 weeks if you have not lost at least 5 percent of your initial body weight. Your doctor may also recommend stopping treatment if there are concerns about increased blood pressure or other concerns with the safety or tolerability of this medicine. Buy Mysimba Online.
What Mysimba contains
The active substances are:
- Naltrexone hydrochloride and bupropion hydrochloride.
Each tablet contains 8 milligrams of naltrexone hydrochloride, equivalent to 7.2 milligrams of naltrexone, and 90 milligrams of bupropion hydrochloride, equivalent to 78 milligrams of bupropion.
The other ingredients are:
- Tablet core: microcrystalline cellulose, hydroxypropyl cellulose, lactose anhydrous, lactose
monohydrate, cysteine hydrochloride, crospovidone, magnesium stearate, hypromellose, edetate disodium, colloidal silicon dioxide, and indigo carmine aluminium lake (E132).
- Filmcoating: poly(vinyl alcohol), titanium dioxide (E171), macrogol (3350), talc and indigo carmine aluminium lake (E132).
How Mysimba works
Naltrexone is a pure opiate antagonist and has little or no agonist activity. The mechanism of action of naltrexone in alcoholism is not understood; however, involvement of the endogenous opioid system is suggested by preclinical data. Naltrexone is thought to act as a competitive antagonist at mc, κ, and δ receptors in the CNS, with the highest affintiy for the μ receptor. Naltrexone competitively binds to such receptors and may block the effects of endogenous opioids. This leads to the antagonization of most of the subjective and objective effects of opiates, including respiratory depression, miosis, euphoria, and drug craving. The major metabolite of naltrexone, 6-β-naltrexol, is also an opiate antagonist and may contribute to the antagonistic activity of the drug.
The exact way that Mysimba works is not fully understood, but the two active substances, naltrexone and bupropion, act on the parts of the brain that control food intake and energy balance, as well as reducing the effect of the part of the brain that controls the pleasure associated with eating food. When given together, their actions reduce appetite and the amount that patients eat, and increase energy expenditure, helping them to stick to a calorie-controlled diet and to reduce their body weight.
What benefits of Mysimba have been shown in studies? Buy Mysimba Online.
The effects of Mysimba in reducing body weight have been shown in 4 main studies involving around 4,500 obese or overweight patients, in which Mysimba was compared with placebo (a dummy treatment). Patients in the studies were given the medicine as part of a weight loss programme involving counselling and advice on diet and exercise. The main measures of effectiveness were the percentage reduction in body weight over 28 or 56 weeks of treatment, and the proportion of patients who achieved at least a 5% weight reduction; the studies also looked at the number of patients who achieved at least a more stringent 10% reduction in weight, and the results were analysed using various methods to take account of the number of patients who did not complete the studies (around 50% over one year).
In three of the studies, the average weight loss in patients treated with Mysimba was around 3.7 to 5.7%, compared with 1.3 to 1.9% with placebo; the proportion of Mysimba-treated patients who achieved 5% weight loss ranged from 28 to 42% compared with 12 to 14% with placebo. About 13 to 22% of those taking Mysimba achieved at least a 10% reduction in weight, while 5 to 6% of placebo-treated patients did so.
In the other study, in which patient counselling was also more intensive, the overall weight loss was greater over the study period: 8.1% with Mysimba and 4.9% with placebo. Some 46% and 30% of patients given Mysimba achieved 5 and 10% weight reductions respectively, compared with 34% and 17% respectively with placebo.
The degree of improvement with Mysimba over placebo was similar using different methods of analysis, although the benefits were smallest with the most conservative methods that assumed patients who did not complete the study would not have seen any improvement. The treatment effect was more marked in patients who completed 56 weeks of treatment, or who had lost at least 5% of their original body weight by 4 months.
Why is Mysimba approved?
The Agency’s Committee for Medicinal Products for Human Use (CHMP) considered that although the effectiveness of the medicine in promoting weight loss was limited, it was sufficient to be clinically significant, and mandatory re-assessment of treatment after 4 months should ensure that the medicine only continues to be used in those in whom the medicine provides adequate benefit. Regarding safety, although the CHMP had some concerns about possible effects on the heart and blood vessels (cardiovascular outcomes) and a slightly increased risk of seizures (fits), the most common side effects were largely manageable, as patients could stop taking the medicine if they were bothersome. Interim data from an ongoing study of cardiovascular outcomes were reviewed during the assessment although the CHMP also recommended ongoing monitoring of the medicine’s cardiovascular effects.On the balance of the available evidence the CHMP decided that Mysimba’s benefits are greater than its risks and recommended that it be approved for use in the EU.
How is Mysimba used?
Mysimba is available as prolonged-release tablets containing 7.2 mg naltrexone and 78 mg bupropion and can only be obtained with a prescription. Prolonged-release means that naltrexone and bupropion are released slowly from the tablet over a few hours.
Treatment with Mysimba is started with a single tablet each morning, with the dose gradually increased over 4 weeks to the recommended dose of two tablets twice a day, preferably taken with food.
Patients should have their response and tolerability to the medicine checked regularly and treatment should be stopped in patients who have certain side effects such as an increase in blood pressure. Mysimba should also be stopped if patients have not lost at least 5% of their initial body weight after 4 months of treatment.
How long does Mysimba last? Buy Mysimba Online.
When you first start Mysimba, a single pack of 112 tablets lasts 5 weeks.
Your medicine should be taken as advised by us. When you take Mysimba you will gradually increase your dose over a four-week period until you reach what is called the maintenance dose. This is the dose at which you will continue to take Mysimba.
You increase your dose as follows:
Once you’ve pass the 4-week dose-escalation period and have achieved the maintenance dose, a single pack of 112 tablets lasts 4 weeks
How long does Mysimba take to work?
The guidance issued by the drug company which produces Mysimba suggests that improvements in well being may be seen by week eight of treatment. Clinical studies with Mysimba have been performed in more than 4,500 patients who were overweight or obese. In these studies, Mysimba in combination with a reduced-calorie diet and physical exercise had significant effects on weight. Mysimba is seen to be effective if you have lost 5% or more of your body weight by week 16 of treatment.
If after 16 weeks on Mysimba you have not lost 5% of your body weight, the treatment may be deemed unsatisfactory and your prescription may be discontinued. Whilst this may feel disheartening, it’s important to remember that if Mysimba doesn’t work for you there are other approaches we can help you with here at Crystal Pharmacy.
What measures are being taken to ensure the safe and effective use of Mysimba?
A risk management plan has been developed to ensure that Mysimba is used as safely as possible. Based on this plan, safety information has been included in the summary of product characteristics and the package leaflet for Mysimba, including the appropriate precautions to be followed by healthcare professionals and patients.
In addition, the company that markets Mysimba will produce an information pack for doctors prescribing the medicine, including guidance on stopping treatment in patients who do not respond or if there are concerns about side effects. It will also carry out a further study to assess the effect of the medicine on the heart and blood vessels.
What’s the difference between Xenical (Orlistat) and Mysimba?
Xenical has an active ingredient called Orlistat, and is a highly popular medication that has been available to buy online for quite some time. It works by stopping around a third of the fat in food from being absorbed into your system during digestion.
Mysimba however is a relatively new and innovative weight loss treatment and is designed to reduce hunger cravings and work as an effective appetite suppressant. The medication can even take some pleasure away from eating. With a lesser appetite and cravings, you can then begin to lose weight together with healthy eating and exercise, making it ideal for those who struggle to lose weight through traditional means. Suitable patients may buy appetite suppressants online such as Mysimba via our safe and secure online consultation service.
Do not take Mysimba:
– if you are allergic to naltrexone, to bupropion, or to any of the other ingredients of this medicine (listed in section 6);
– if you have an abnormally high blood pressure (hypertension) that is not controlled using a medicinal product;
– if you have a condition that causes fits (seizures) or if you have a history of fits;
– if you have a brain tumor;
– if you are usually a heavy drinker and you have just stopped drinking alcohol, or are going to stop while you are taking Mysimba; – if you have recently stopped taking sedatives or medicines to treat anxiety (especially benzodiazepines), or if you are going to stop them while you are taking Mysimba;
– if you have or have had a bipolar disorder (extreme mood swings);
– if you are using any other medicines which contain bupropion or naltrexone;
– if you have an eating disorder or had one in the past (for example, bulimia or anorexia nervosa);
– if you are currently dependent on chronic opiates or opiate agonists (for example methadone), or you are going through acute withdrawal (cold turkey);
– if you are taking medicines for depression or Parkinson’s disease called monoamine oxidase inhibitors (MAOIs) or have taken them in the last 14 days;
– if you have severe liver disease;
– if you have end-stage kidney disease.
Mysimba has been shown to cause fits (seizures) in up to 1 in 1,000 patients. You should inform your doctor before taking this medicine:
• if you have had a serious head injury or head trauma;
• if you regularly drink alcohol (see “Mysimba with alcohol”);
• if you regularly use medicines to help you to sleep (sedatives);
• if you are currently dependent on or addicted to cocaine or other stimulating products;
• if you have diabetes for which you use insulin or oral medicines that may cause low sugar levels in your blood (hypoglycemia); or • if you are taking medicines that may increase the risk of fits (see “Other medicines and Mysimba”). If you have a fit (seizure), you should stop taking Mysimba and consult your doctor immediately. You should stop taking Mysimba immediately and consult your doctor if you are experiencing any symptoms of an allergic reaction such as swelling of the throat, tongue, lips, or face, difficulty swallowing or breathing, dizziness, fever, rash, pain in the joints or in the muscles, itching or hives after taking this medicine. You should talk to your doctor, especially if: Buy Mysimba online without a prescription in the UK and CA, or Australia.
• you have high blood pressure before taking Mysimba because it can become worse. You will have your blood pressure and heart rate measured before you start taking Mysimba. If your blood pressure or heart rate increases significantly, you may need to stop taking Mysimba.
• you have uncontrolled coronary artery disease (a heart disease caused by poor blood flow in the blood vessels of the heart) with symptoms such as angina (characterized by chest pain) or a recent heart attack.
• you already have or have had a condition affecting the circulation of blood in the brain (cerebrovascular disease).
• you have any liver problems before you start Mysimba?
• you have any kidney problems before you start Mysimba?
• you have a history of mania (feeling elated or over-excited, which causes unusual behavior).
• If you are taking medicines for depression, the use of these medicines together with Mysimba can lead to serotonin syndrome, a potentially life-threatening condition.
When you Buy Mysimba Online Learn How to take Mysimba
Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. The initial dose is usually one tablet (8 mg naltrexone hydrochloride / 90 mg bupropion hydrochloride) once a day in the morning. The dose will be gradually adapted as follows:
• Week 1: One tablet once a day in the morning
• Week 2: Two tablets every day, one in the morning and one in the evening
• Week 3: Three tablets every day, two in the morning and one in the evening
• Week 4 and onward: Four tablets every day, two in the morning and two in the evening. The maximum recommended daily dose of Mysimba is two tablets taken twice a day. After 16 weeks and each year after your treatment initiation, your doctor will evaluate whether you should continue to take Mysimba. If you have problems with your liver or kidney, or if you are older than 65, and depending on the severity of your problems, your doctor may carefully consider whether this medicine is suitable for you or recommend that you take a different dose, and monitor you more closely for potential side effects before you get Mysimba For Sale.Your doctor may test your blood before initiating treatment with Mysimba if you have high blood sugar (diabetes) or if you are older than 65 so that your doctor can decide if you should take this medicine or if you need to take a different dose. This medicine is for oral use. Swallow your tablets whole. Do not cut them, chew them or crush them. The tablets should preferably be taken with food. Do not take more Mysimba than you should, if you take too many tablets, you may be more likely to have a fit or other side effects similar to those described Do not delay, contact your doctor or your nearest hospital emergency department immediately. If you forget to take Mysimba Skip the missed dose and take your next dose at the next usual time. Do not take a double dose to make up for a forgotten dose. You may need to take Mysimba for at least 16 weeks to have its full effect. Do not stop taking Mysimba without talking to your doctor first. If you have any further questions on the uses of Mysimba.
Naltrexone is used for the treatment of alcohol dependence and for the blockade of the effects of exogenously administered opioids. Naltrexone has not been shown to provide any therapeutic benefit except as part of an appropriate plan of management for the addictions. Mysimba is also used to associated treatment for these conditions: Alcohol Dependency, BMI >30 kg/m2, Cholestatic pruritus, Opioid Dependence, Severe Pain.
May reduce effects of opiate-containing preparations e.g. those used for cough and cold, diarrhoea and pain. Increased or decreased serum levels with drugs that alter hepatic metabolism. Potentially increased hepatotoxic effects with disulfiram. Increased risk of naltrexone-induced lethargy and somnolence with thioridazine. May increase insulin requirements.Buy Mysimba Online.
Once the Package is registered with a courier we provide a tracking number for monitoring. Our shipping guarantee covers any transportation damage or package loss. We will send you a replacement package free of charge if we confirm that your package has been lost in transit or damaged due to the delivery process. If the item is no longer in stock, we will offer you a refund
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What are the side effects of msyimba?
However, if someone is predisposed to allergic reactions due to medicinal components, then they may feel the common side effects of Msyimba, which include, -dry mouth,
Abdominal pain, nausea, vomiting; anxiety, insomnia, lethargy, headache, musculoskeletal pain; anorexia, aside from any adverse reactions, a Mysimba user feels satiated; hence they don’t eat much.
- Are pregnant or trying to conceive
- Have a history of an eating disorder
- Suffer from severe liver or kidney disease
- Experience uncontrolled hypertension
- Have ever had a seizure
- Have a nervous system tumour
- Experience benzodiazepine or alcohol withdrawal
- Take concomitant treatment containing bupropion or naltrexone
- Anyone who has a history of bipolar disorder
- Patients who are taking antidepressants – especially those on or who have taken monoamine oxidase inhibitors (MAOI) in the last 14 days
- Anyone with a history of depression
- Anyone taking opiate medication or methadone
Hepatic or renal impairment. Monitor LFTs regularly. Patients should be opioid-free for at least 7-10 days prior to initiating naltrexone therapy. Strictly warn patients against the use of opioids while on naltrexone. Monitor for inj-site reactions. Pregnancy, lactation. History of bleeding disorders (including thrombocytopenia).
Frequently asked questions
How effective is Mysimba?
In studies, more than 40% of people taking Mysimba lost 5% of their body weight over the course of 28 or 56 weeks.
Can I drink alcohol while taking Mysimba?
You should avoid or limit alcohol consumption while taking Mysimba for weight loss. Alcoholic drinks are generally high in calories and can put you at an increased risk of complications from obesity.
Will Mysimba affect my ability to drive or operate machinery?
Mysimba may cause you to feel drowsy or dizzy. If you notice that this medicine has this effect on you, you should avoid driving or operating any machinery until you are well enough to do so.
Is Mysimba available on the NHS?
No, Mysimba is not typically available on the NHS. However, it is available from Prescription Doctor’s online private prescription service.
Simply fill out our short medical questionnaire, and our online prescriber will determine whether Mysimba is suitable for you.
How long can I take Mysimba?
You should take Mysimba for at least 16 weeks in order for it to reach its maximum effect.
Mysimba can be taken for as long as required to achieve your weight loss goal. You should not stop taking Mysimba without first speaking to your doctor.
Can I use Mysimba alongside other weight loss treatments, like Orlistat or Saxenda?
Do not use Mysimba together with Orlistat or Saxenda. If you wish to change the weight loss medication you are taking, speak to your doctor.
Firstly, we make sure we build a sound and perfect relationship with all our clients and provide 24 hours of assistance, we are also promoting a positive, helpful, and friendly environment for our customers and make sure all customers dispatch with a good and satisfactory impression.
Pregnancy and breastfeeding
If you’re pregnant or breastfeeding you should not take Mysimba. If you’re worried about weight gain or the effects that obesity could have on your pregnancy, ask your doctor, pharmacist, or healthcare team for advice. They’ll be more than happy to provide safe options that could help you to lose or manage your weight without causing a risk to your baby. For example, they may suggest a diet or exercise programme that’s safe to do during your pregnancy and will help your growing child get the nutrients they need from you.
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Your prescriber will usually suggest that you don’t drink alcohol while you’re taking Mysimba. Alcohol can increase your chances of experiencing fits, seizures or mental disorder events while using this treatment. These tablets can also reduce your tolerance for alcohol, which could make you more vulnerable to the effects of drinking. However, if you drink a lot at the moment you shouldn’t stop drinking suddenly, as this can also increase your risk of having a fit. Reduce your alcohol intake gradually and ask your GP for help if you need it.
You may feel dizzy or sleepy after taking Mysimba weight loss tablets, and this can affect your concentration and your ability to drive. If you experience this or any other symptoms which could make it difficult for you to concentrate or react properly you should not attempt to drive or use any tools or machinery until the effects have passed and you are sure you are safe to do so. If this treatment causes fits, fainting, or muscle weakness you should not attempt to drive and should speak to your doctor right away.
This product is a medicine; make sure to speak to your doctor or Chemist4U pharmacist before taking this product if you have an underlying medical problem or are taking any other medicine or complementary therapy. If your symptoms get worse or continue after taking this product, contact us or your doctor.
If you are pregnant, trying to become pregnant, or breastfeeding, speak to your doctor or our pharmacist before taking this product. If you suffer from any allergies, ask your doctor or our pharmacist if this medicine is right for you.
Store all medicines out of sight and reach of children.
Please read the included leaflet carefully before using this product.
Please contact your GP if appropriate regarding this product.
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Store in a cool, dry place which is below 30 degrees C. Do not use this product if the expiry date printed on the original packaging has passed. Keep out of sight and reach of children.Buy Mysimba Online.